Project HOPE first arrived in Malawi in 1989 offering HIV/AIDS prevention in collaboration with the Private Hospital Association of Malawi (PHAM).

Project HOPE has since continued to create HIV/AIDS prevention and education programs as well as expanded some programs by addressing HIV/AIDS tuberculosis (TB) co-infection and the prevention of other sexually transmitted infections (STI). Initiatives in Malawi have included a child survival program, anemia prevention, a breastfeeding education project to help reduce the infant morbidity and mortality rate, a village health bank initiative to strengthen family units caring for orphans, and a community health partnership in the district of Mulanje to strengthen service delivery and build human and institutional capacity.

Always working at the community level to increase knowledge and reduce the stigma associated with TB/HIV, in 2006 Project HOPE also initiated a five-year project in the Mulanje and Phalombe districts to support the National TB Program and improve case management and treatment outcomes. The program seeks to better control TB by training health care workers, improving the quality of lab networks, setting up community sputum collection points and mobilizing the community.

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