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When Typhoon Haiyan (locally known as Yolanda) struck the Philippines in November 2013, Project HOPE responded quickly, sending much needed medicines, supplies and medical volunteers. In the seven months following the typhoon, Project HOPE sent more than 80 medical volunteers to badly damaged sites in Capiz and Cebu Province. In Cebu, Project HOPE also rebuilt damaged health infrastructure and strengthened health systems in the geographically remote Camotes Islands by hiring Filipino health professionals. Since November 2013, HOPE has shipped more than $24 million of medicines, vaccines (including MMR) and medical supplies, which have helped more than 270,000 patients. 

In April 2014 Project HOPE launched a three-year Maternal, Neonatal, Child Health and Nutrition Project aimed at reducing maternal, neonatal and infant morbidity and mortality. The strategies of this program include outreach to men, women and youth with unmet need for family planning and strengthening the quality of maternal health services.

Project HOPE medical volunteers also participated in humanitarian assistance missions to the Philippines in partnership with the United States Navy in 2012 and 2014.

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